2024, Vol. 12, Issue 1, Part A

The Tau protein plays a pivotal role in the organization and reinforcement of microtubules, which are essential for the normal functioning of neurons and the brain. Under diseased conditions, several pathological alterations occur in the tau protein. These changes lead to the aggregation of tau protein and the formation of neurofibrillary tangles (NFT) and paired helical filaments (PHF), which are common hallmarks of Alzheimer's disease and other tauopathies. Bioactive compound derived from the medicinal plant Bombax ceiba were examined for their potential in targeting the tau protein, with the objective of assessing their effectiveness in combating Alzheimer's disease. In this research article, we focus on the major bioactive constituents of plant Bombax ceiba in some solvent’s methanol, ethanol, and water along with binding affinity of selected bioactive compounds: Lupeol (PubChem CID 259846), Beta-Sitosterol (PubChem CID 222284), and Quercetin (PubChem CID 5280343), in comparison to the binding affinity of the standard drug Donepezil (PubChem CID 3152). The results showed that that bioactive compounds like Alkaloids, Cardiac Glycosides, Flavonoids, Phenolic compound, sugar (carbohydrate), Tannins, and Saponins are mostly present in ethanol, normal (water), boil (water), and methanol, whereas amino acid are not present in any of it. The extract derived from the leaves of the plant species exhibited notable antioxidant potential as determined through the DPPH (2, 2-diphenyl-1-picrylhydrazyl) radical scavenging assay. In antioxidant analysis, Ethanol exhibits the highest percentage of inhibition against the standard solution (vitamin C). During docking among the three selected ligands, lupeol exhibited the highest binding affinity value of -5.24, while the binding affinity of the standard drug was -4.98.