2024, Vol. 12, Issue 4, Part A

author(s)
Dhanush KR and Ashoka babu VL

abstract
This review set out to methodically assess the body of research on the effectiveness of lupeol in wound healing. We looked through the MEDLINE, SCIDIRECT, and SPRINGER databases for original research that was published till December 2023. Seven reviewers assessed the title, abstract, and whole manuscript for every research. Out of the 635 studies that we found, only 04 underwent additional evaluation on the exclusion criteria, clinical trials were applied and 03 non animal experiment model (In-vitro) were included. Lupeol based formulation were more effective for wound recovery, isolation of lupeol from different plants like Betula pendula brich, Derris scandens, Bowdichia virgilioides, Bergia ammannioides etc. The lupeol induced a reduction in time closure, and effective was reported in both in-vito & In-vivo wound models included diabetic wound. In addition, our study indicates that lupeol appear to promote wound healing; however, Taken together, these findings demonstrate that lupeol are a class of molecules with significant promise that leads for the development of new drugs to treat skin injury. Lupeol have been shown to induce cell migration, cell proliferation, collagen deposition, anti-inflammatory, anti-angiogenesis, anti-oxidation & Cytotoxicity effect.