Neem-clove polyherbal tablet: A synergistic effect of anti-bacterial and analgesic
Siddhiraj More, Abhishek Desai and Nilesh Chougule
In the realm of herbal medicine, the quest for potent antimicrobial agents has led to the exploration of traditional remedies. In this study, we present the formulation and evaluation of an angesic and antibacterial poly herbal tablet derived from two renowned botanical sources: neem (Azadirachta indica) and clove (Syzygium aromaticum). Neem and clove are esteemed for their rich phytochemical profiles, boasting compounds like azadirachtin, nimbin, eugenol, and eugenol acetate, known for their antibacterial, antifungal, and anti- inflammatory properties. The poly herbal tablet was meticulously formulated, optimizing the proportions of neem and clove extracts to harness their synergistic effects. The tablet's efficacy was assessed through comprehensive antimicrobial assays against a panel of clinically relevant bacterial strains, including both Gram-positive and Gram-negative species. Additionally, its angelic properties were evaluated through in vitro and in vivo studies, shedding light on its potential therapeutic applications beyond its antibacterial prowess. The results revealed promising antibacterial activity against a spectrum of pathogens, underscored by the tablet's ability to inhibit bacterial growth and biofilm formation. Furthermore, the tablet exhibited notable angelic effects, demonstrating anti-inflammatory properties in cell culture models and alleviating symptoms in animal models of inflammation.