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Journal of Medicinal Plants Studies
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P-ISSN: 2394-0530, E-ISSN: 2320-3862

2024, Vol. 12, Issue 4, Part D

Effects of the aqueous leaves extract of Eremomastax speciosa (Hochst.) Cufod. (Acanthaceae) administered along the perinatal and postnatal phases in rats

Nchegang Benjamin, Egbe B Besong, Wankeu-Nya Modeste, Bonoy Lamou, Enow-Orock Enonchong George and Tan Paul Vernyuy

Ethnopharmacological relevance: Eremomastax speciosa (Hochst) Cufod (Acanthaceae) has long been used as a natural medicine for the treatment of ailments and also infertility problems in men and women.
Objective: This study investigated the effects of oral chronic administration of Eremomastax speciosa during the perinatal and lactation periods in female Wistar rats.
Materials and Methods: Four groups of pregnant rats were treated orally with the extract (at doses 0, 250, 500 and 1000 mg/kg) from day 1 to day 6 (pre-implantation period), day 7 to day 14 (organogenesis period), day 15 to day 21 (fetal period) of pregnancy, and from day 22 to day 52 of the lactation period. Reproductive performance, anthropometric, fetal development, haematological and biochemical parameters were measured and histological sections of ovaries and uteri were realized.
Results: The results revealed non-significant increases in haematological parameters and significant increase (p<0.05) of sex ratio, total number of pups, live births, fertility, lactation and viability index in the animals treated at the high dose (1000 mg/kg) compared with the control. After a 30 days post-treatment washing, haematological defense parameters increased in the test groups. Treatment with extract did not influence the length of gestation. ASAT and ALAT activities increased in animals treated with the extract but decreased after post-treatment washing. Development parameters in F1 and F2 offspring from extract-treated groups showed little variation compared with the controls. No signs of organ toxicity were observed.
Conclusion: The extract of E. speciosa administered during the perinatal/lactation period had no adverse effects on the development of offspring at the first and second generations.
Pages : 341-351 | 147 Views | 81 Downloads


Journal of Medicinal Plants Studies
How to cite this article:
Nchegang Benjamin, Egbe B Besong, Wankeu-Nya Modeste, Bonoy Lamou, Enow-Orock Enonchong George, Tan Paul Vernyuy. Effects of the aqueous leaves extract of Eremomastax speciosa (Hochst.) Cufod. (Acanthaceae) administered along the perinatal and postnatal phases in rats. J Med Plants Stud 2024;12(4):341-351. DOI: 10.22271/plants.2024.v12.i4d.1727
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