2024, Vol. 12, Issue 5, Part A

author(s)
Samradhnyee Sawant, Prachi Khochage and Nilesh Chougule

abstract
This study focuses on the preparation and assessment of a polyherbal gel that includes extracts from Babool (Acacia nilotica), Tridax procumbens, and Nirgundi (Vitex negundo) to treat bacterial infections. Because of these plants' strong antibacterial qualities, traditional medicine holds them in high respect. In order to get the best consistency and stability for topical use, the ethanolic extracts of these herbs were combined with an appropriate gel foundation throughout the formulation process. Tests were conducted on the gel's antimicrobial activity against common harmful microorganisms, such as Escherichia coli and Staphylococcus aureus. The existence of bioactive substances with antibacterial potential, such as flavonoids, tannins, and alkaloids, was verified by phytochemical screening. The outcomes showed that the polyherbal gel had strong antibacterial properties that were on par with those of prescription antibiotics, indicating that it might be used as a natural substitute for treating bacterial skin infections. The gel's physicochemical characteristics, such as its pH, viscosity, and spreadability, were assessed to make sure it satisfies the requirements for patient compliance and application simplicity.