Preclinical Evaluation of the effect of Pijusballi Rasa (PLRM) on steroidal and gonadotropin hormone profile on chronic administration to the male Sprague-Dawley rats
Pijusballi Rasa (PLRm), an Ayurvedic formulation for dysentery, was administered chronically to male Sprague-Dawley rats at a dose of 400 mg/kg to evaluate its impact on steroidal and gonadotropin hormone profiles. After 28 days, serum levels of Dehydroepiandrosterone sulfate (DHEA-S), total testosterone, 17-beta-Estradiol (E2), progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured. Results showed a statistically significant increase (P=0.035) in serum progesterone, alongside a 54.92% reduction in LH levels. FSH levels decreased by 71.01%, though this change was not statistically significant (P=0.354). Despite these hormonal shifts, PLRm did not cause harmful effects on the overall health of the rats. This suggests that PLRm selectively influences certain hormone levels, particularly progesterone and LH, without major adverse consequences. Further studies are recommended to better understand its long-term safety and underlying mechanisms.
TS Farah Mousumi, Farhana Kishoara, Shahela Ahmed, MD Moniruzzaman Monir, Rajib Halder, Mabiya Sultana Samapti. Preclinical Evaluation of the effect of Pijusballi Rasa (PLRM) on steroidal and gonadotropin hormone profile on chronic administration to the male Sprague-Dawley rats. J Med Plants Stud 2024;12(5):54-58. DOI: 10.22271/plants.2024.v12.i5a.1748