2024, Vol. 12, Issue 6, Part A

author(s)
Shivangi N Naik, Sangeetha L Rajbanshi and Sahitya C Pandanaboina

abstract
The current work has been carried out to assess the neuroprotective effect of Hibiscus rosa sinensis flower extract during ethanol induced toxicity. Rats were grouped as vehicle control, disease control (20% w/v Ethanol 5 ml/kg), additionally, two sets of rats received Ethanol and H. rosa sinensis extracts at 125 mg/kg and 250 mg/kg doses respectively. Internal control group received Ethanol in addition to Vitamin E 100 mg/kg orally. Post treatment regimen, brain oxidative stress markers were measured. H. rosa sinensis flower extract treated group in the dose of 250 mg/kg showed significant (p<0.001) decrease in MDA and significant increase in GSH Level (p<0.01), SOD (p<0.05) CAT (p<0.001), while significant decrease in NO production (p<0.01) indicates reduction in oxidative stress when compared to ethanol treated group. Our results indicate that H. rosa sinensis flower extracts possess neuroprotective properties, elevating the brain antioxidants levels and protecting brain cells from ethanol stress.