2024, Vol. 12, Issue 6, Part B

author(s)
Usha MS, Diya Jangada, D Sanjana, N Harini, Harshitha Dandina, B Pragathi and Dona Suresh

abstract
The study focuses on the biofilm inhibition and eradication capabilities of Artocarpus heterophyllus (jackfruit) and Mangifera indica (mango) extracts against clinical bacterial isolates namely Escherichia coli, Klebsiella spp., and Staphylococcus aureus. Biofilm formation, a key factor in bacterial resistance and chronic infections, was targeted using methanolic, ethanolic, and water extracts derived from seeds, pulp, and peels of these plants. The results demonstrated significant biofilm inhibition and eradication. Ethanolic extracts were found to be more effective, methanolic extracts showing better inhibition compared to water extracts. Mangifera indica was found to be more effective when compared to Artocarpus heterophyllus. When biofilm inhibition studies were carried out ethanolic extract of Mangifera indica seed and pulp both at 25 mg/ml concentration were found to be showing good inhibition against E. coli. Ethanolic extract of Artocarpus heterophyllus seed at 10 mg/ml concentration, ethanolic extract of Artocarpus heterophyllus pulp at 25 mg/ml concentration and ethanolic extract of Mangifera indica seed at 150 mg/ml were found to be effective against Klebsiella spp. Similarly, Methanolic extract of Mangifera indica seed and ethanolic extract of Mangifera indica peel both at 25 mg/ml were found to be effective against S. aureus. When biofilm eradication studies were carried out methanolic extract of Mangifera indica peel at 25 mg/ml concentration was found to be effective against E. coli. Whereas ethanolic extract of Mangifera indica seed at 150 mg/ml concentration, methanolic extract of Mangifera indica pulp at 200 mg/ml concentration and methanolic extract of Mangifera indica peel at 150 mg/ml concentration were found to show good inhibition against Klebsiella spp. Similarly, ethanolic extract of Mangifera indica seed and ethanolic extract of Mangifera indica peel both at 25 mg/ml concentractions were found to be effective against S. aureus.