Synergistic effect of aqueous and alcoholic extracts of L. nobilis, R. officinalis and Q. rubra plants against bacteria isolated from burn patients
Dhafer Rahman Abed Al-janabi and Enas Abd al-Raouf Ammar Semysim
This study was performed at the Faculty of Science / University of Kufa from November 2022 to March 2023 designed to investigate the ability of Synergistic effect of aqueous and alcoholic extracts of L. nobilis, R. officinalis and Q. rubra plants against bacteria isolated from burn patients and hhe chemical composition of each plant is known. Three concentrations of methanol, hexane, cold water and hot water extracts (100, 200 and 400) mg/ml were performed.
Sixty-eight samples were collected from the Burns Medical Center in Najaf Governorate. Males and females in different age groups. 35 isolates of Pseudomonas aeruginosa, 18 isolates of Staphylococcus aureus and 15 isolates of Klebsiella pneumonia were tested. Ten antibiotics were selected in the antibiotic sensitivity test. The results showed that all three concentrations had good antibacterial effect. Also, the hot water solvent was found to be more effective on Sido bacteria with a rate of 37.167 ± 0.22mm. The results also showed that P. aeruginosa, and n-hexane solvent gave the highest rate of inhibition diameter against S. aureus bacteria 37.333 ± 0.36 mm while for K. pneumonia bacteria methane solvent was the highest 33.500 ± 0.14mm. The study highlights the synergistic effect of combining plant extracts, which outperforms individual plant extracts and even some antibiotics, such as Imipenem. The results emphasize the potential of these plants as alternatives to conventional antibiotics, particularly in combating antibiotic-resistant bacteria. Overall, these findings support the potential use of L. nobilis, R. officinalis, and Q. rubra as effective antimicrobial agents in the treatment of resistant bacterial infections.
Dhafer Rahman Abed Al-janabi, Enas Abd al-Raouf Ammar Semysim. Synergistic effect of aqueous and alcoholic extracts of L. nobilis, R. officinalis and Q. rubra plants against bacteria isolated from burn patients. J Med Plants Stud 2025;13(1):57-62. DOI: 10.22271/plants.2025.v13.i1a.1791