2025, Vol. 13, Issue 3, Part D

author(s)
Tooba Hayat, Tabassum Latafat, Mursaleen Naseer, Jamal Azmat, S Javed Ali and Sadaf

abstract
Delphinium denudatum (Jadwar) is a medicinal herb known for its neuroprotective
properties and potential applications in neurological disorders. Rich in
bioactive alkaloids such as delphinine, staphisagrine, and β-sitosterol, it
exhibits antioxidative, anti-inflammatory, and neuromodulatory effects. Studies
suggest that D. denudatum enhances antioxidant enzyme activity,
including Superoxide Dismutase (SOD) and Catalase (CAT), reducing oxidative
stress in neurodegenerative conditions like Parkinsonism. Additionally, its
anticonvulsant properties, observed in Maximal Electroshock (MEST) and Pentylenetetrazole
(PTZ)-induced seizures, highlight its role in epilepsy management. The herb
also demonstrates anxiolytic and anti-fatigue effects, improving cognitive and
emotional well-being. Furthermore, its analgesic and anti-inflammatory
properties support its use in neuroinflammatory conditions. Given its broad
therapeutic scope, D. denudatum offers a promising natural alternative
for neuroprotection and neurological disorder management. However, further
clinical research is necessary to validate its efficacy, establish safe
dosages, and explore its mechanisms of action in human subjects