2025, Vol. 13, Issue 4, Part C

author(s)
Swapna Reddy Kasi Reddy, G Pragna, G Naga Udaya, Mohammad Atheeb, M Tulsi Das, Papagatla Poli Reddy and KNV Rao

abstract

Alzheimer’s disease is progressive and irreversible neurodegenerative disorder that gradually leads to the state of dementia. The pathophysiology of AD includes the deposition of amyloid beta peptides forming senile plaques at axon terminals, and the development of neurofibrillary tangles due to the accumulation of hyperphosphorylated tau proteins with in the brain cells. Currently, available drugs to treat AD like AChE inhibitors, NMDA receptor antagonists exert symptomatic relief but don’t decrease progression of the disease and have many side effects. Medicinal plants have played vital role in world health. In spite of the great advances observed in modern medicine in recent decades, plants still make an important contribution to health care.

Aim and Objective: The present study is done to evaluate the extract for preliminary phytochemical screening, TLC analysis and effect of plant Portulaca oleracea extract on experimental models of Alzheimer’s disease using locomotor activity.

Materials and Methodology: The methanolic plant extract are subjected to Elevated Plus Maze, Morris Water Maze, Rota rod test on Swiss albino mice. Measurement of Locomotor Activity were done to assess memory & cognitive functioning. Diazepam (3mg/kg body weight, intraperitoneally) was used for the induction of Alzheimer’s like effects on Swiss albino mice and Donepezil (1mg/kg body weight, oral) used as a standard treatment.

Results: In extract treated groups there is decrease in transfer latency time in dose dependent manner and escape latency time. It was found that methanolic extract of plant having significant Anti -Alzheimer’s activity when compared with standard and vehicle control. Diazepam treated group showed significant increase in escape latency when compared with vehicle control; which indicates impairment in learning and memory.

Conclusion: Both the extract and standard significantly reversed the memory loss induced by diazepam and improved learning and memory. By identifying and isolating the phytoconstituents responsible for Anti Alzheimer’s activity, we may find a breakthrough in the treatment of brain related problems.