2025, Vol. 13, Issue 4, Part D

author(s)
Lalit Aloysious, Vikas Jha, Siddhi Dhuri, Sushant Sole, Tanmayee M, Ayaaz Khan and Anil Kumar

abstract
Herbal plants have long served as foundational sources for drug development across various traditional and modern medicinal systems. Their bioactive constituents phytochemicals play a pivotal role in the discovery of novel therapeutic agents. Given their broad-spectrum activity and lower toxicity profiles, phytochemicals have drawn considerable interest for combating drug-resistant pathogens, including Clostridium perfringens, the primary causative agent of gas gangrene. This review systematically compiles and evaluates plants reported to exhibit anti-clostridial activity, with an emphasis on activity on Clostridium perfringens. By consolidating this data, our study aims to support the identification of promising plant-based leads for future anti-clostridial drug development. These findings highlight promising plant-based avenues for combating resistant Clostridial infections.