2025, Vol. 13, Issue 5, Part C

author(s)
Aditya Singh, Preeti Kumari, Nisha Gupta and Nakul Gupta

abstract
Due to Helicobacter pylori infection, NSAID use, and imbalances between mucosal defense and aggressive gastric factors, gastrointestinal disorders especially peptic and gastric ulcers remain major global health concerns. The need for safer and more sustainable alternatives is highlighted by the fact that traditional pharmacological therapy, such as proton pump inhibitors and antibiotic regimens, is frequently constrained by drug resistance, recurrence, and side effects. Herbal remedies have become more well-known in recent years due to their diverse gastroprotective properties, which include anti-inflammatory, antioxidant, anti-secretory, mucosal protective, and anti-H. pylori properties. By modifying important molecular pathways like NF-?B, MAPK, and prostaglandin signaling, a number of medicinal plants, such as Glycyrrhiza glabra, Curcuma longa, Aloe vera, Zingiber officinale, and Camellia sinensis, demonstrate effectiveness in preventing ulcers and promoting mucosal healing. Helicobacter pylori infection, NSAID use, and imbalances between mucosal defense and aggressive gastric factors continue to be significant global health challenges, particularly peptic and gastric ulcers. The need for safer and more sustainable alternatives is highlighted by the fact that traditional pharmacological therapy, such as proton pump inhibitors and antibiotic regimens, is frequently constrained by drug resistance, recurrence, and side effects. Herbal remedies have become more well-known in recent years due to their diverse gastroprotective properties, which include anti-inflammatory, antioxidant, anti-secretory, mucosal protective, and anti-H. pylori properties. By modifying important molecular pathways like NF-?B, MAPK, and prostaglandin signaling, a number of medicinal plants, such as Glycyrrhiza glabra, Curcuma longa, Aloe vera, Zingiber officinale, and Camellia sinensis, demonstrate effectiveness in preventing ulcers and promoting mucosal healing.