In vitro antimycotic activity of ethanolic young leaves extract of Argemone mexicana L.
P Shivakumar Singh and GM Vidyasagar
Antimycotic Activity (Agar well diffusion technique) of ethanolic leaf extract of Argemone mexicana L. (Papaveraceae) was evaluated against mycotic fungi namely Trichophyton rubrum, Microsporum gypseum, dimorphic fungi such as Candida albicans, and saprophytic fungi like Aspergillus flavus, Aspergillus niger and pathogenic bacteria like, Staphylococcus aureus, E. coli, Bacillus subtilis. Maximum antimycotic activity was observed against M gypseum (13 mm) followed by T. rubrum (11 mm), C. albicans (9 mm), A. flavus (8.4 mm), A. niger (8 mm). Among bacteria tested, B. subtilis showed maximum inhibition of 8.2 mm followed by E. coli (8 mm) and S. aureus (7.5 mm). The MIC was determined against all the test fungal and bacterial strains. The sensitivity of the tset organisms varied with the species and strains. The study provides basis for the isolation and purifiction of anti-dermatophytic compounds from the leaves of Argemone mexicana L.